苦鬼臼毒素

英文名称：Picropodophyllotoxin
CAS号：477-47-4
分析标准品,≥98%
分子式 C22H22O8 分子量414.41

基本信息:

密度1.37
存贮条件 贮存温度2-8℃
描述
别名 IGF-1R 抑制剂;PPP;(5R,5aS,8aR,9R)-9-Hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)fur[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; NSC 36407; Picropodophyllin; PPP;IGF-1R Inhibitor, PPP;AXL1717
生化机理
Picropodophyllotoxin (PPP) is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Picropodophyllotoxin exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II. Picropodophyllotoxin inhibits IGF1R autophosphorylation (IC50 ~ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. Picropodophyllotoxin exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.
应用 苦鬼臼毒素是胰岛素样生长因子-I（IGF-I）受体激酶抑制剂。