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中药标准品
|
产品编号 |
英文名称 |
CAS号 |
包装 |
|
Y3592 |
Emodin |
518-82-1 |
可根据客户要求订制 |
英文名称：Emodin
CAS号：518-82-1
分析标准品，≥96.0% (HPLC)
分子式 C15H10O5 分子量270.24
基本信息:
密度 1.583
熔点 256-257°C
存贮条件 储存温度 2-8°C
描述
产品介绍 溶于乙醇，略溶于乙醚、氯仿、苯，不溶于水。溶于苛性碱水溶液、碳本酸钠水溶液，氨溶液中显樱红色。
别名 大黄素 ;朱砂莲甲素,1,3,8-三羟基-6-甲基蒽醌;1,3,8-Tri-hydroxy-6-methyl-anthra-quinone 6-Methyl-1,3,8-tri-hydroxy-anthra-quinone Emodol Frangula-emodin
生化机理
Description:
IC50 Value: observed at 72 hr were as follows: 66.9 uM, Hep3B cells; 74.36 uM, HepG2 cells; and 101.5 uM, Huh7 cells [1].
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, molds, and lichens, and an active ingredient of various Chinese herbs. Emodin exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways.
in vitro: At 6h after emodin treatment, the levels of GDF15, CYP1A1, CYP1B1, and CYR61 were upregulated [1]. Emodin increased the resting tension of gallbladder smooth muscle strips and inhibited voltage-dependent K(+) current in a dose-dependent manner. When 10 microM emodin was applied to gallbladder smooth muscle cells for 3-6 min., the amplitude of voltage-dependent K(+) current was decreased by 31.5 +/- 0.5% at +40 mV, and this inhibitory effect mostly recovered after washout [2].
Clinical trial: N/A
应用 抑制NF -κB活化及粘附分子的表达。酪蛋白激酶2（CK2的）抑制剂.
熔点 256-257°C
存贮条件 储存温度 2-8°C
描述
产品介绍 溶于乙醇，略溶于乙醚、氯仿、苯，不溶于水。溶于苛性碱水溶液、碳本酸钠水溶液，氨溶液中显樱红色。
别名 大黄素 ;朱砂莲甲素,1,3,8-三羟基-6-甲基蒽醌;1,3,8-Tri-hydroxy-6-methyl-anthra-quinone 6-Methyl-1,3,8-tri-hydroxy-anthra-quinone Emodol Frangula-emodin
生化机理
Description:
IC50 Value: observed at 72 hr were as follows: 66.9 uM, Hep3B cells; 74.36 uM, HepG2 cells; and 101.5 uM, Huh7 cells [1].
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, molds, and lichens, and an active ingredient of various Chinese herbs. Emodin exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways.
in vitro: At 6h after emodin treatment, the levels of GDF15, CYP1A1, CYP1B1, and CYR61 were upregulated [1]. Emodin increased the resting tension of gallbladder smooth muscle strips and inhibited voltage-dependent K(+) current in a dose-dependent manner. When 10 microM emodin was applied to gallbladder smooth muscle cells for 3-6 min., the amplitude of voltage-dependent K(+) current was decreased by 31.5 +/- 0.5% at +40 mV, and this inhibitory effect mostly recovered after washout [2].
Clinical trial: N/A
应用 抑制NF -κB活化及粘附分子的表达。酪蛋白激酶2（CK2的）抑制剂.
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