鹅去氧胆酸

产品编号：Y0702

英文名称：Chenodeoxycholic acid

CAS号 474-25-9

分析标准品

分子式 C24H40O4 分子量392.58

基本信息:

敏感性对光敏感

密度1.128

存贮条件密封避光保存。

描述

产品介绍味苦、有异臭。易溶于乙醇、甲醇、丙酮和乙酸，几乎不溶于水、石油醚和苯。

别名鹅去氧胆酸 ;脱氧鹅胆酸；鹅脱氧胆酸；3α,7α-二羟基胆质酸；3α,7α-二羟基-5-β-胆烷酸;

生化机理

Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism. Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism. EC50 concentrations for activation of FXR range from 13-34 μM. In cells, Chenodeoxycholic Acid also binds to bile acid binding proteins (BABP) with a reported stiochiometery of 1:2. Chenodeoxycholic Acid toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess Chenodeoxycholic Acid contributes to liver and intestinal cancers.

应用主要用于合成熊去氧胆酸。

胆石溶解剂，用于胆固醇高而引起的结石、胆道炎和胆囊炎等。