邻苯二甲酸单(2-乙基己基)酯

产品编号：Y0049

英文名称：Mono-2-ethylhexyl Phthalate

CAS号 4376-20-9

分析标准品

分子式 C16H22O4 分子量278.34

基本信息:

属性

存贮条件  储存温度2-8℃

描述

别名  邻苯二甲酸单(2-乙基己基)酯;2-Ethylhexyl Hydrogen Phthalate Monooctyl Phthalate Phthalic Acid Mono-2-ethylhexyl Ester Phthalic Acid Monooctyl Ester

生化机理  MEHP is a bioactive metabolite of DEHP which inhibits the 17,20 lyase activity of CYP17. MEHP has been shown to modulate the expression of a broad spectrum of genes, including the downregulation of the steroidogenic genes Insl3, expressed in Leydig cells, and Inha, expressed in both Leydig and Sertoli cells during fetal life. It has also been shown to induce apoptosis in germ and Sertoli cells via disruption of junction complexes.

应用  DEHP的一种具有生物活性的代谢物。