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英文名称 Anti-phospho-ZFP36L1 (Ser92)
中文名称： 磷酸化EGF应答因子1抗体
别 名 butyrate response factor 1 (phospho S92); Berg36; BRF1; butyrate response factor 1; C3H type like 1; cMG1; early response factor Berg36; EGF inducible protein CMG1; EGF response factor 1; ERF1; RNF162B; TIS11B; zinc finger protein.
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep
产品类型 一抗 磷酸化抗体
研究领域 细胞生物 发育生物学 信号转导 干细胞 生长因子和激素 转录调节因子 锌指蛋白 表观遗传学
蛋白分子量 predicted molecular weight: 36kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human butyrate response factor 1 around the phosphorylation site of Ser92 [SF(p-S)EG]
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 EGF response factor 1 is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. TIS11B, a relative of TTP, localizes to the nucleus and may function as a transcription factor involved in regulating the growth factor response. It is an evolutionarily conserved protein containing two C3H1-type zinc fingers and a repeating cys-his motif. TIS11B is an mRNA binding protein and is known to interact with the 3’-untranslated region of VEGF mRNA, thereby decreasing its stability. This suggests that TIS11B is a potential target in antiangiogenic therapy. In addition, TIS11B may also be an important regulator of myogenesis, as its expression is upregulated during murine myoblast differentiation.
Function : Butyrate response factor 1 is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating Cys-His motif. This putative nuclear transcription factor probably functions in regulating the response to growth factors.
Subcellular Location : Nuclear.
Similarity : Contains 2 C3H1-type zinc fingers.
Database links : UniProtKB/Swiss-Prot: Q07352.1
中文名称： 磷酸化EGF应答因子1抗体
别 名 butyrate response factor 1 (phospho S92); Berg36; BRF1; butyrate response factor 1; C3H type like 1; cMG1; early response factor Berg36; EGF inducible protein CMG1; EGF response factor 1; ERF1; RNF162B; TIS11B; zinc finger protein.
详细介绍：
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep
产品类型 一抗 磷酸化抗体
研究领域 细胞生物 发育生物学 信号转导 干细胞 生长因子和激素 转录调节因子 锌指蛋白 表观遗传学
蛋白分子量 predicted molecular weight: 36kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human butyrate response factor 1 around the phosphorylation site of Ser92 [SF(p-S)EG]
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相关资料：
产品介绍 EGF response factor 1 is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. TIS11B, a relative of TTP, localizes to the nucleus and may function as a transcription factor involved in regulating the growth factor response. It is an evolutionarily conserved protein containing two C3H1-type zinc fingers and a repeating cys-his motif. TIS11B is an mRNA binding protein and is known to interact with the 3’-untranslated region of VEGF mRNA, thereby decreasing its stability. This suggests that TIS11B is a potential target in antiangiogenic therapy. In addition, TIS11B may also be an important regulator of myogenesis, as its expression is upregulated during murine myoblast differentiation.
Function : Butyrate response factor 1 is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating Cys-His motif. This putative nuclear transcription factor probably functions in regulating the response to growth factors.
Subcellular Location : Nuclear.
Similarity : Contains 2 C3H1-type zinc fingers.
Database links : UniProtKB/Swiss-Prot: Q07352.1
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