产品中心
相关产品
标记一抗
英文名称Anti-TREX1/FITC
中文名称:FITC标记的系统性红斑狼疮相关蛋白TREX1抗体
别 名ATRIP; AGS 1; AGS1; AGS-1; Aicardi Goutieres syndrome 1; ATIP; ATM and Rad3 related interacting protein; ATM and Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; Atrip; ATRIP_HUMAN; Deoxyribonuclease III dnaQ/mutD (E. coli) like; DKFZp434J0310; DKFZp762J2115; DNase III; DRN 3; DRN3; FLJ12343; MGC20625; MGC26740; Three prime repair exonuclease 1; TREX 1; TREX1; TREX1 protein; MGC21482; 3' repair exonuclease 1; 3'-5' exonuclease TREX1.
规格:100ul
说 明 书100ul
研究领域免疫学 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
产品应用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量87kDa
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ATRIP(152-194aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 and Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM and ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM and Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication and damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex and are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization
Function:
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
Subunit:
Interacts with ATR. Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP.
Subcellular Location:
Nucleus. Redistributes to discrete nuclear foci upon DNA damage.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylated by ATR.
Similarity:
Belongs to the ATRIP family.
中文名称:FITC标记的系统性红斑狼疮相关蛋白TREX1抗体
别 名ATRIP; AGS 1; AGS1; AGS-1; Aicardi Goutieres syndrome 1; ATIP; ATM and Rad3 related interacting protein; ATM and Rad3-related-interacting protein; ATR interacting protein; ATR-interacting protein; Atrip; ATRIP_HUMAN; Deoxyribonuclease III dnaQ/mutD (E. coli) like; DKFZp434J0310; DKFZp762J2115; DNase III; DRN 3; DRN3; FLJ12343; MGC20625; MGC26740; Three prime repair exonuclease 1; TREX 1; TREX1; TREX1 protein; MGC21482; 3' repair exonuclease 1; 3'-5' exonuclease TREX1.
详细介绍：
规格:100ul
说 明 书100ul
研究领域免疫学 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
产品应用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量87kDa
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ATRIP(152-194aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相关资料：
产品介绍background:
DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 and Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM and ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM and Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication and damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex and are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization
Function:
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
Subunit:
Interacts with ATR. Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP.
Subcellular Location:
Nucleus. Redistributes to discrete nuclear foci upon DNA damage.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylated by ATR.
Similarity:
Belongs to the ATRIP family.
