川皮苷

产品编号	英文名称	CAS号	包装
Y3756	Nobiletin	478-01-3	可根据客户要求订制

产品编号：Y3756

英文名称：Nobiletin
CAS号：478-01-3
分析标准品
分子式 C21H22O8 分子量402.39

基本信息:

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敏感性 对热敏感
熔点 138°C
溶解性 Soluble in methanol ( ), water (<1 mg/ml), chloroform, DMSO (81 mg/ml), and ethanol (3 mg/ml).
存贮条件 储存温度 -20°C
描述
产品介绍 Nobiletin is a flavanoid with antioxidant and anti-inflammatory properties found in the rind of tangerines. The compound has been observed to inhibit the phosphorylation of MEK (mitogen-activated protein kinase). Nobiletin has also been documented to suppress the expression of MMP-1 (matrix metalloproteinases), MMP-3 and MMP-9 that are involved in the breakdown of the extracellular matrix during tumor metastasis. In vitro studies of Nobiletin on varying cancer cell lines and on the chick egg has shown the anti-angiogenic effects of Nobiletin through down regulation of ERK 1, ERK 2 and c-Jun N-terminal kinase, and transcriptional factors c-Jun and Stat3. The compound also suppressed proliferation, migration and tube formation on matrigel of HUVEC cells stimulated with growth supplement. Nobiletin has demonstrated to attenuate NF-κB transcriptional activation, NO and PGE2 production, NOS2 (inducible nitric oxide synthase) and Cox-2 (cyclooxygenase-2) expression.
别名 3',4',5,6,7,8-六甲氧基黄酮;蜜橘黄素;2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one; 3′,4′,5,6,7,8-Hexamethoxyflavone
生化机理 Nobiletin suppresses the expression of matrix metalloproteinases 1, 3 and 9, which participate in the break down of the extracellular matrix during tumor metastasis. Nobiletin is also involved in the increased expression of tissue inhibitor of matrix metalloproteinase 1 further preventing extracellular matrix degradation during tumor invasion. This bioflavonoid is believed to achieve both of these functions by disrupting the signal transduction pathway of Ras-Raf-MEK.
应用 An antioxidant and anti-inflammatory that Inhibits the phosphorylation of MEK.