紫杉醇

英文名称：Paclitaxel
CAS号：33069-62-4
分析标准品,≥99%
分子式 C47H51NO14 分子量853.91

基本信息:

旋光率 -49 ° (C=1, MeOH)
密度1.39
熔点 213-216°C
存贮条件 储存温度2-8°C
描述
产品介绍 Paclitaxel是一种微管聚合物稳定剂，作用于人内皮细胞，IC50为0.1 pM
别名 Taxol;Taxol
生化机理 Taxol, an antineoplastic and antimicrotubule agent, posses mechanisms of cytotoxic action and has a broad antineoplastic spectrum compared to the vinca alkaloids. Studies have shown that Taxol is an inhibitor of neurite outgrowth and initiation by destroying normal control of microtuble assemly in growing neurites and removing tubulin from the cytoplasm. At lower concentrations Taxol displays the capacity to slightly enhance the mechanisms of microtubule assembly in neurons, and in turn changes the morphogenetic properties of growing neurites. The mechanism for microtuble formation occurs by binding of Taxol to the N-terminal region of β-tubulin. These new microtubules are highly stable and resist depolymerization therefore preventing normal cell division and arresting cell cycle at the G2/M phase. It has been reported that Taxol also causes apoptotic cell death, internucleosomal DNA fragmentation, and inhibition of protein isoprenylation. Taxol is a potential activator of PKA and Raf
应用 有效的抗肿瘤的药物;结合β-微管蛋白的N -端区域，促进了高度稳定的微管形成体，抵制解聚，防止正常细胞分裂和捕