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英文名称 Anti-phospho-Acetyl Coenzyme A Carboxylase beta (Ser220)
中文名称 磷酸化乙酰辅酶A羧化酶抗体
别 名 Acetyl Coenzyme A Carboxylase beta (phospho S221); Acetyl Coenzyme A Carboxylase beta (phospho Ser221); p-Acetyl Coenzyme A Carboxylase beta (phospho S221); Acetyl Coenzyme A Carboxylase; ACAS2; AceCS; Acetate CoA ligase; Acetyl CoA synthetase; Acetyl coenzyme A synthetase cytoplasmic; Acetyl-CoA synthetase; ACS; ACSS2; Acyl activating enzyme; Acyl CoA synthetase short chain family member 2; EC 6.2.1.1; MYH7B; ACACB; ACC beta; ACC2; ACCB; Acetyl CoA carboxylase 2; Acetyl CoA carboxylase beta; Biotin carboxylase; COA2; HFA1; ACACB_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human
产品类型 一抗 磷酸化抗体
研究领域 肿瘤 心血管 细胞生物 转录调节因子
蛋白分子量 predicted molecular weight: 265kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Acetyl Coenzyme A Carboxylase beta around the phosphorylation site of Ser220
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function : ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Subunit : Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
Subcellular Location : Endomembrane system. Note=May associate with membranes.
Tissue Specificity : Predominantly expressed in the heart, skeletal muscles and liver.
Similarity : Contains 1 ATP-grasp domain.
Contains 1 biotin carboxylation domain.
Contains 1 biotinyl-binding domain.
Contains 1 carboxyltransferase domain.
Database links : UniProtKB/Swiss-Prot: O00763.3
中文名称 磷酸化乙酰辅酶A羧化酶抗体
别 名 Acetyl Coenzyme A Carboxylase beta (phospho S221); Acetyl Coenzyme A Carboxylase beta (phospho Ser221); p-Acetyl Coenzyme A Carboxylase beta (phospho S221); Acetyl Coenzyme A Carboxylase; ACAS2; AceCS; Acetate CoA ligase; Acetyl CoA synthetase; Acetyl coenzyme A synthetase cytoplasmic; Acetyl-CoA synthetase; ACS; ACSS2; Acyl activating enzyme; Acyl CoA synthetase short chain family member 2; EC 6.2.1.1; MYH7B; ACACB; ACC beta; ACC2; ACCB; Acetyl CoA carboxylase 2; Acetyl CoA carboxylase beta; Biotin carboxylase; COA2; HFA1; ACACB_HUMAN.
详细介绍：
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human
产品类型 一抗 磷酸化抗体
研究领域 肿瘤 心血管 细胞生物 转录调节因子
蛋白分子量 predicted molecular weight: 265kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Acetyl Coenzyme A Carboxylase beta around the phosphorylation site of Ser220
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相关资料：
产品介绍 Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function : ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Subunit : Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
Subcellular Location : Endomembrane system. Note=May associate with membranes.
Tissue Specificity : Predominantly expressed in the heart, skeletal muscles and liver.
Similarity : Contains 1 ATP-grasp domain.
Contains 1 biotin carboxylation domain.
Contains 1 biotinyl-binding domain.
Contains 1 carboxyltransferase domain.
Database links : UniProtKB/Swiss-Prot: O00763.3
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