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英文名称 Anti-ATP6V1B2/V-ATPase B2
中文名称 ATP6V1B2蛋白抗体
别 名 ATP6B1B2; ATP6B2; ATP6V1 B2; ATP6V1B 2; ATP6V1B2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B isoform 2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B2; ATPase H+ transporting, lysosomal (vacuolar proton pump) beta polypeptide 56/58kD isoform 2; ATPase, H+ transporting, lysosomal V1 subunit B2; brain isoform; Endomembrane proton pump 58 kDa subunit; H+ transporting two sector ATPase; HO 57; HO57; V ATPase B2 subunit; V ATPase subunit B 2; V type proton ATPase subunit B, brain isoform; V-ATPase subunit B 2; V-type proton ATPase subunit B; Vacuolar ATP synthase subunit B brain isoform; Vacuolar H+ ATPase 56,000 subunit; Vacuolar H+ ATPase 56000 subunit; Vacuolar H+ATPase B2; Vacuolar proton pump subunit B 2; VAT B2; VATB 2; VATB; VATB2; VATB2_HUMAN; Vma 2; Vma2; VPP 3; VPP3.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Cynomolgus Monkey, Orangutan
产品类型 一抗
研究领域 肿瘤 细胞生物 免疫学 神经生物学 信号转导 新陈代谢 表观遗传学
蛋白分子量 predicted molecular weight: 56kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human ATP6V1B2/V-ATPase B2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. The V-ATPase V1 B subunit exists as two isoforms. In the inner ear, the V-ATPase B1 isoform functions in proton secretion and is required to maintain proper endolymph pH and normal auditory function. The gene encoding the human V-ATPase B1 isoform maps to chromosome 2cen-q13. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. The V-ATPase B2 isoform is expressed in kidney and is the only B isoform expressed in osteoclasts. The gene encoding the human V-ATPase B2 isoform maps to chromosome 8p22-p21.
Function : Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subunit : V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).
Subcellular Location : Endomembrane system. Melanosome. Endomembrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Similarity : Belongs to the ATPase alpha/beta chains family.
Database links : UniProtKB/Swiss-Prot: P21281.3
中文名称 ATP6V1B2蛋白抗体
别 名 ATP6B1B2; ATP6B2; ATP6V1 B2; ATP6V1B 2; ATP6V1B2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B isoform 2; ATPase H+ transporting lysosomal 56/58kDa V1 subunit B2; ATPase H+ transporting, lysosomal (vacuolar proton pump) beta polypeptide 56/58kD isoform 2; ATPase, H+ transporting, lysosomal V1 subunit B2; brain isoform; Endomembrane proton pump 58 kDa subunit; H+ transporting two sector ATPase; HO 57; HO57; V ATPase B2 subunit; V ATPase subunit B 2; V type proton ATPase subunit B, brain isoform; V-ATPase subunit B 2; V-type proton ATPase subunit B; Vacuolar ATP synthase subunit B brain isoform; Vacuolar H+ ATPase 56,000 subunit; Vacuolar H+ ATPase 56000 subunit; Vacuolar H+ATPase B2; Vacuolar proton pump subunit B 2; VAT B2; VATB 2; VATB; VATB2; VATB2_HUMAN; Vma 2; Vma2; VPP 3; VPP3.
详细介绍：
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Cynomolgus Monkey, Orangutan
产品类型 一抗
研究领域 肿瘤 细胞生物 免疫学 神经生物学 信号转导 新陈代谢 表观遗传学
蛋白分子量 predicted molecular weight: 56kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human ATP6V1B2/V-ATPase B2
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相关资料：
产品介绍 Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. The V-ATPase V1 B subunit exists as two isoforms. In the inner ear, the V-ATPase B1 isoform functions in proton secretion and is required to maintain proper endolymph pH and normal auditory function. The gene encoding the human V-ATPase B1 isoform maps to chromosome 2cen-q13. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. The V-ATPase B2 isoform is expressed in kidney and is the only B isoform expressed in osteoclasts. The gene encoding the human V-ATPase B2 isoform maps to chromosome 8p22-p21.
Function : Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subunit : V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).
Subcellular Location : Endomembrane system. Melanosome. Endomembrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Similarity : Belongs to the ATPase alpha/beta chains family.
Database links : UniProtKB/Swiss-Prot: P21281.3
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