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标记一抗
英文名称Anti-POP1/FITC
中文名称:FITC标记的感染性蛋白唯一蛋白1抗体
别 名PAAD domain only protein; POP1; PYDC1; Pyrin domain containing 1; Pyrin only protein 1; PYDC1_HUMAN.
规格:100ul
说 明 书100ul
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量10kDa
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ASC2/POP1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
The death domain (DD) superfamily of proteins share one or more of the following domains: the DD, DED (death-effector domain), CARD (caspase-recruitment domain) and PYD (Pyrin domain). Each of these domains is characterized by a canonical death domain fold, which consists of a bundle of five or six antiparallel α-helices. As their names suggest, these domains play prominent roles in programmed cell death. ASC2 (apoptosis-associated speck-like protein containing a CARD 2), also known as Pyrin-only protein 1 or PADD-only protein 1, is an 89 amino acid member of the DD superfamily that contains one Pyrin domain. Localized to the cytoplasm, ASC2 interacts with ASC to modulate NF-κB and pro-caspase-1 regulation. ASC2 is predominantly expressed in monocytes, macrophages and granulocytes.
Function:
Associates with apoptosis-associated specklike proteincontaining a CARD domain (ASC) and modulates its ability tocollaborate with pyrin and cryopyrin in NF-kappa-B andpro-caspase-1 activation. Suppresses kinase activity of NF-kappa-Binhibitor kinase (IKK) complex, expression of NF-kappa-B induciblegenes and inhibits NF-kappa-B activation by cytokines and LPS.
Subunit:
Interacts with PYCARD/ASC.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Predominantly expressed in monocytes,macrophages and granulocytes.
Post-translational modifications:
Phosphorylated.
Similarity:
Contains 1 DAPIN domain.
中文名称:FITC标记的感染性蛋白唯一蛋白1抗体
别 名PAAD domain only protein; POP1; PYDC1; Pyrin domain containing 1; Pyrin only protein 1; PYDC1_HUMAN.
详细介绍：
规格:100ul
说 明 书100ul
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量10kDa
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ASC2/POP1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相关资料：
产品介绍background:
The death domain (DD) superfamily of proteins share one or more of the following domains: the DD, DED (death-effector domain), CARD (caspase-recruitment domain) and PYD (Pyrin domain). Each of these domains is characterized by a canonical death domain fold, which consists of a bundle of five or six antiparallel α-helices. As their names suggest, these domains play prominent roles in programmed cell death. ASC2 (apoptosis-associated speck-like protein containing a CARD 2), also known as Pyrin-only protein 1 or PADD-only protein 1, is an 89 amino acid member of the DD superfamily that contains one Pyrin domain. Localized to the cytoplasm, ASC2 interacts with ASC to modulate NF-κB and pro-caspase-1 regulation. ASC2 is predominantly expressed in monocytes, macrophages and granulocytes.
Function:
Associates with apoptosis-associated specklike proteincontaining a CARD domain (ASC) and modulates its ability tocollaborate with pyrin and cryopyrin in NF-kappa-B andpro-caspase-1 activation. Suppresses kinase activity of NF-kappa-Binhibitor kinase (IKK) complex, expression of NF-kappa-B induciblegenes and inhibits NF-kappa-B activation by cytokines and LPS.
Subunit:
Interacts with PYCARD/ASC.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Predominantly expressed in monocytes,macrophages and granulocytes.
Post-translational modifications:
Phosphorylated.
Similarity:
Contains 1 DAPIN domain.
