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英文名称Anti-ASMTL/FITC
中文名称:FITC标记的ASMTL蛋白抗体
别 名Acetylserotonin N methyltransferase like; Acetylserotonin O methyltransferase like; ASMTLX; ASMTLY; ASTML; N acetylserotonin O methyltransferase like protein; ASML_HUMAN.
规格:100ul
说 明 书100ul
研究领域细胞生物 免疫学 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量69kDa
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ASMTL
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍background:
Serotonin, a monoamine neurotransmitter associated with neuronal modulation of emotions, is synthesized by serotonergic neurons of the central nervous system through metabolism of the essential amino acid L-tryptophan. In the pineal gland, serotonin can be transformed into the circadian regulatory hormone melatonin by ASMT (acetylserotonin O-methyltransferase) which catalyzes the final reaction in the synthesis pathway. ASMTL (N-acetylserotonin O-methyltransferase-like protein) is a 621 amino acid protein with a putative catalytic S-adenosyl-L-methionine domain that shares high genetic homology to ASMT. The ASMTL protein is encoded by a gene from the PAR1 region of the X and Y chromosomes, which is considered to be a fusion product of two evolutionarily disparate genes. ASMTL, with potential cytoplasmic localization, is abundant in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Low expression levels are found in spleen, small intestine and leukocytes
Function:
Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.
Similarity:
In the N-terminal section; belongs to the maf family.
Database links:
UniProtKB/Swiss-Prot: O95671.3
中文名称:FITC标记的ASMTL蛋白抗体
别 名Acetylserotonin N methyltransferase like; Acetylserotonin O methyltransferase like; ASMTLX; ASMTLY; ASTML; N acetylserotonin O methyltransferase like protein; ASML_HUMAN.
详细介绍：
规格:100ul
说 明 书100ul
研究领域细胞生物 免疫学 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
产品应用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量69kDa
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ASMTL
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相关资料：
产品介绍background:
Serotonin, a monoamine neurotransmitter associated with neuronal modulation of emotions, is synthesized by serotonergic neurons of the central nervous system through metabolism of the essential amino acid L-tryptophan. In the pineal gland, serotonin can be transformed into the circadian regulatory hormone melatonin by ASMT (acetylserotonin O-methyltransferase) which catalyzes the final reaction in the synthesis pathway. ASMTL (N-acetylserotonin O-methyltransferase-like protein) is a 621 amino acid protein with a putative catalytic S-adenosyl-L-methionine domain that shares high genetic homology to ASMT. The ASMTL protein is encoded by a gene from the PAR1 region of the X and Y chromosomes, which is considered to be a fusion product of two evolutionarily disparate genes. ASMTL, with potential cytoplasmic localization, is abundant in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Low expression levels are found in spleen, small intestine and leukocytes
Function:
Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.
Similarity:
In the N-terminal section; belongs to the maf family.
Database links:
UniProtKB/Swiss-Prot: O95671.3
