CD96抗体

英文名称  Anti-CD96 
中文名称  CD96抗体 
别    名  ANCO 1; ANCO1; Ankyrin repeat containing cofactor 1; Ankyrin repeat domain 11; Ankyrin repeat domain containing protein 11; LZ16; T13; ANR11_HUMAN. 
详细介绍：

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浓    度  1mg/1ml 
规 格  0.2ml/200μg  
抗体来源  Rabbit  
克隆类型  polyclonal 
交叉反应  Human, Mouse, Rat, Dog, Cow, Horse, Sheep   
产品类型  一抗    
研究领域  肿瘤 细胞生物 免疫学 干细胞 淋巴细胞 t-淋巴细胞 肿瘤细胞生物标志物  
蛋白分子量  predicted molecular weight: 298kDa 
性    状  Lyophilized or Liquid 
免 疫 原  KLH conjugated synthetic peptide derived from human ANKRD11 
亚    型  IgG 
纯化方法  affinity purified by Protein A 
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 
产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500 
（石蜡切片需做抗原修复） 
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

相关资料：

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产品介绍 CD96 antigen, also designated T cell surface protein tactile (T cell activation, increased late expression) precursor, is a type I membrane protein and is a member of the immunoglobulin supergene family of proteins. The gene encoding for the CD96 protein maps to chromosome 3q13.13-q13.2. During the late phases of the immune response, CD96 is involved in adhesive interactions of activated, both helper and cytotoxic, NK and T cells. It interacts with CD155. CD96, shows increased expression after NK and T cell activation. It can also be found actively engaging diseased cells and moving in inflamed areas after NK and T cells have moved through the endothelium. CD96 is involved in antigen presentation and/or lymphocyte activation. The protein, which may form a homodimer, is expressed on normal T cell lines and some transformed T cells.
Function : May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation.
Subunit : Interacts with the PAS region of the p160 coactivators. 
Subcellular Location : Membrane.
Tissue Specificity : Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells.
DISEASE : Defects in CD96 are a cause of C syndrome (CSYN) [MIM:211750]; also called Opitz trigonocephaly syndrome. This syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges, multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psychomotor retardation and hypotonia. Note=A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.
Defects in CD96 are a cause of C-like syndrome (CLSYN) [MIM:605039]; also called Opitz trigonocephaly-like syndrome. The C-like syndrome seems to be a severe form of the C syndrome. It is controversial whether there is (1) a gradient of spectrum in the C syndrome, from the mild form (C syndrome) to the severe form (C-like syndrome), or (2) genetic heterogeneity among the patients with the C syndrome.
Similarity : Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.
Database links : UniProtKB/Swiss-Prot: Q6UB99.3