白藜芦醇

密度1.359
存贮条件 储存温度-20°C
描述
产品介绍 无味，完全溶解于乙醇。
别名 芪三酚;3,4',5-三羟基芪;反式-1,2-(3,4',5-三羟基二苯基)乙烯;(E)-5-[2-(4-羟苯基)-乙烯基]-1,3-苯二酚;3,4′,5-Trihydroxy-trans-stilbene;trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene
生化机理
Resveratrol is a phenolic phytoalexin found in grape skin and other plants. Resveratrol produced neurotrophic effects on cultured DA neurons. Resveratrol could attenuate oxidant-induced mitochondrial damage in embryonic rat cardiomyocytes by inactivating GSK-3β via cGMP/PKG signaling pathway independent of NO-related mechanism. Because Resveratrol has anti-inflammatory, anti-oxidant, and hypotriglyceridemic effects, its supplementation may beneficially affect the increased cardiovascular risk of healthy smokers. Resveratrol merits investigation as a potential cancer chemopreventive agent in humans. trans-Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity. trans-Resveratrol is also a selective inhibitor of cyclooxygenase-1 (COX-1). It inhibits COX and peroxidase activities of COX-1 with ED50 values of 15 and 3.7 M, respectively; with essentially no inhibition of the COX activity
应用 COX1选择性抑制剂。
白藜芦醇是一种酚类植物抗毒素,发现于葡萄皮和其他植物中。它具有细胞内抗氧化活性激活去乙酰化酶SIRT1。白藜芦醇的抗糖尿病、神经保护和抗脂特性都可能是去乙酰化酶SIRT1激活所致。