滨蒿内酯

产品编号	英文名称	CAS号	包装
Y3687	6,7-Dimethoxycoumarin	120-08-1	可根据客户要求订制

产品编号：Y3687

英文名称：6,7-Dimethoxycoumarin  

CAS号：120-08-1
分析标准品,≥98%  
分子式 C11H10O4 分子量206.19  

基本信息:

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密度  1.248
熔点   143-145°C
溶解性   Soluble in DMSO (15 mg/ml), and water (partly miscible).
描述  
产品介绍   Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMKII in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells.
别名   蒿属香豆素;Scoparone;6,7-Dimethylesculetin;6,7-Dimethoxy-2H-chromen-2-one;6,7-Dimethoxy-2-benzopyrone
应用   An agent that can up-regulate the expression and activate CAR